"What's in your Creatine?"
By Will Brink
Brink's Bodybuilding Revealed  & Fat Loss Revealed

Why I had to write this article

The supplement industry in the United States is by and large a self-regulated industry. Unlike other countries, we (the USA) don't have government constantly telling us what we can and cannot do with our supplements. Though they have been trying to discredit supplements for decades, the FDA and pharmaceutical/ medical industrial complex have largely failed to do so. As a self-regulated industry, we must do just that. Let me state here and now, I am all for self-regulation and totally against government regulation when it comes to supplements. When we find gross problems, we have to expose them no matter what the cost. Any supplement that is found to be potentially dangerous, terribly misleading, or otherwise a total scam, must be exposed as such.

If we don't do it, then we allow the "powers that be" (who have an interest in discrediting the supplement industry) to get one step closer to the Orwellian scenario of other countries. I thought long and hard as to whether or not I should write this article, but in the end, as a person of good conscience and ethics, I knew I had to. In the end, it will cost the entire supplement industry far more than any one loss could ever cost a single company if problems with a certain product are not exposed.

As far as I am concerned, this is us airing out or own dirty inter-industry laundry and policing our own, instead of waiting for the "don't confuse us with the facts" popular media or other groups to come after the supplement industry. I know it must sound like I am almost apologizing for writing this article, and in a way I am. It could potentially cost certain people a great deal of money. On the other hand, it could also make some other person a great deal of money, depending on where they fall (this will make more sense to the reader as you read along). In the end, the truth can never been denied, it can only be delayed. With each day of delay, the cost to everyone goes up. Nuff said.

Are you getting more than you paid for?

Most of us are always happy when we get more than we paid for, but in some instances, it's not such a good idea. If we are buying say vitamin C and the label says "500mg per capsule" and laboratory analysis reveals it contains 600mg, then that is a great thing. However, if we test a product and not only does it contain what the label claims, but several other compounds we did not know were in there and had no place being in there, then that's a completely different story. For example, when the amino acid L-Tryptophan was taken off the market for the death of several people, it was not because of the L-Tryptophan itself, but because of a chemical contaminant found in a batch of the L-tryptophan that was not supposed to be there. This was a perfect example of getting more than you paid for in the worst possible scenario. What I am going to write about in this article certainly is not as bad as the L-tryptophan fiasco, but it could be a potential health concern.

So after that long, cryptic, and bizarre introduction, what am I getting at? Recently, a company tested the five largest creatine manufacturers products and tested the products of various distributors from the USA, Germany, Great Britain, and other countries. At this time, the company who did the testing wishes to remain anonymous, lest they be accused of throwing stones at the supplement industry. However, this is a very large and reputable company and they stand behind their test results.

Also, I know this company to be one of the worlds most reputable companies, so I had no problems with their testing results or methods. The test results came to me through the back door so to speak. So what was tested for and what did it reveal? The creatine products were tested for: Dicyandiamide, Creatinine, Dihydrotriazine, and sodium content. What did the tests reveal? It revealed that there is a wide range of differences between creatine products from different manufacturers. The purity level of all the creatine products were also tested and they generally fell between 88 and 92%. Now before you go off yelling "but my creatine says 99% pure creatine monohydrate on the bottle," you have to remember there is a small amount of water in creatine monohydrate.

Before we bother with the results, we need to take a look at the chemicals that were tested for-and subsequently found- in these samples. What really bothered me was the fact that there is little safety research on some of these chemicals, most notably the dihydrotriazine. I did Med-line searches, looked through various chemical data related books (i.e. the Merck Index and other publications), made many phone calls to chemists, spent hours on the internet, and was amazed to find so little real safety data on some of these materials.

Considering the fact that some creatine products contain fairly high amounts of these chemicals, the lack of solid safety data did not make me feel very comfortable. The major point of this is really the amount of creatine ingested in relation to the amount of contaminant present. It's not that a compound has a small amount of some contaminant per se, but the levels of the contaminant is found in relation to how much of the product is consumed is the real question. In the December issue of Health and Nutrition Breakthroughs (p12, 1997) Dr. Podell addressed the same concern regarding creatine as I have when he stated "...there is the potentially important issue of product purity. Given the high doses of creatine most people take, even a minute toxic impurity could have a dangerous effect. Unfortunately we cannot be sure of a manufacturers' quality controls."

As we all know, people don't just take 500mg (1/2 a gram) of creatine, they take 10,000mg (10g), 20,000mg (20g), or even 30,000mg (30g) of creatine per day, so even a small amount of a contaminant (such as the dihydrotriazine) can add up quickly. For example, one creatine product contained as much as 18,000 parts per million (PPM) of Dicyandiamide. If a person is taking in ten grams per day of creatine, that's 180 mg of this chemical a day. If you are taking in 30g a day of creatine-as is often the case during the loading phase-you would be getting a whopping 540mg a day of dicyandiamide!

The Chemicals

Dicyandiamide (DC): DC is actually a derivative of one of the starting chemicals (cyanamide) used in creatine production. DC is formed during the production of creatine products, and large amounts found in a product are considered the result of an incomplete or inefficient process. A quality creatine product will contain very small amounts, less than 20-50ppm. At this time, DC does not appear to be a particularly toxic chemical. Oral studies with animals (rats and dogs) lasting up to 90 days have not shown serious toxicity or carcinogenic effects, and acute poisoning also takes very high amounts. DC appears to have many uses in the chemical industry. Some of the more interesting is the use of DC in the production of fertilizers, explosives, fire proofing compounds, cleaning compounds, soldering compounds, stabilizer in detergents, modifier for starch products, and a catalyst for epoxy resins.

At the concentrations found in some of the creatine products (see below), it's a good thing this stuff does not appear to be particularly toxic. However, as far as I am concerned, I don't want to be eating the stuff. One interesting point as it relates to DC and toxicity is, if one looks at the safety sheet on the stuff it states that DC breaks down into hydrogen cyanide gas when exposed to a strong acid. Hydrogen cyanide gas is very toxic and has been used as a chemical warfare agent! As Bruce Kneller points out (see side bar), stomach acid, which has a PH of 2, is a very strong acid. Is even a tiny amount of hydrogen cyanide gas produced from the intake of large amounts of DC? The chemist I spoke to did not seem to think so and the safety data with animals would tend to support this, but who knows. Bruce might be overreacting a bit on this, but it's better to lean on the cautious side with such things. Bottom line, it's best not to be eating large amounts of DC in this writer's opinion.

Dihydrotriazine (DT): DT appears to be the real mystery chemical as far as potentially toxic contaminants found in some creatine products. One company had it listed as "...Dihydrotriazine is often found in various creatine products. This substance is a byproduct of non-optimized creatine productions and consequently widely spread over creatine products. Dihydrotriazine is a compound with unknown pharmaceutical and toxicological properties." It was virtually impossible to find any useful safety data on this chemical.

However, DT is part of a large family of chemicals known as the "triazines." It is an organic base with many derivatives. Some of these derivatives are toxic while others are known to be non-toxic, so it is very difficult to come to any real solid opinion regarding the potential toxicity of this chemical. One chemist I spoke to from a major pharmaceutical supply company said to me on the phone "it's safe to say that there will be major differences in toxicity between derivatives since 'triazine' simply means possessing three C=N-H groups. Some derivatives are highly toxic."

Bill Roberts, a medicinal Chemist and writer for Dan Duchaine's Dirty Dieting news letter commented after I sent him over this information: "There really is no way to say just how high a chronic intake of this chemical [these chemicals] is safe in humans from the information given. If the amounts were very small, say a few milligrams per week, it's a reasonable guess that there would probably be no problem.

But if a creatine brand has say 1% of this impurity [these impurities] then people are going to be consuming thousands of milligrams of this compound [these compounds] over time. I think we have to be concerned about taking so much of something that really isn't well studied in humans for safety. It would certainly be unwise to assume thattoxicity is not an issue. If the consumer has a choice between a creatine brand that contains this impurity [these impurities] in significant amounts, and one that is more pure, I'd certainly recommend spending the extra money and obtaining the purer product."

So as you can see, we are left with a major question mark regarding DT. For me, the less I know about a chemical the less of it I want to find in any product I am ingesting. Though this chemical might turn out to be perfectly harmless, I think it should not be found in any amount and thus should be non-detectable (n.d.) in the ppm range until we know more about this chemical. As you can see from the tests, some companies have n.d. amounts while others have far more than that. I find this unacceptable, and so should you.

Creatinine: Creatinine is one of the easy compounds to discuss on this list. Creatinine is actually a natural byproduct of creatine metabolism in the human body and of creatine production. A small amount can be found in every creatine product. However, in some products large amounts can be found, as high as 7700 ppm in one case (see chart). It is probably safe to say that the ingestion of creatinine is a safe endeavor. There is some research that links the ingestion of creatinine from meats with increased colon cancer incidence, but in all honesty I would not put much stock in that or get all worked up about it . The point is, when I buy creatine I want to eat creatine, not creatinine. Though a natural byproduct of creatine metabolism, it does not have any ergogenic effects and therefore I don't want large amounts of it in my creatine, period. A high quality creatine product should contain less than 100ppm of creatinine in my opinion.

Sodium: Like the aforementioned creatinine, sodium is an easy one to talk about. Also, like creatinine, it is a generally safe thing to ingest at normal intakes. At the levels found in these creatine products, the amount of sodium added to the diet is very small and should pose no problems, even to the most sodium phobic person. However, like I said before, when I pay for creatine I want creatine, not sodium. The lowest sodium content was 20ppm and the highest was 500ppm. I leave it to the reader to decide what is a tolerable sodium content to them.

Conclusion

Believe it or not, the company who did the testing told me that although those were the main chemicals they tested for, some creatine products read like a who's who of different chemical compounds, though they admitted that they are usually found in trace amounts. As for the consumer, if it were me, I would demand the HPLC test results from whom ever I was buying my creatine from regarding the chemicals listed in this article. If you don't care, that's OK also. As for me, I will make sure my creatine comes only from companies and distributors who sell creatine made by the large German company, or other companies, who clearly have their collective act together when it comes to producing an ultra pure creatine product. Bottom line? The expression "creatine is creatine" no longer holds true. However, a high quality creatine product it still the best thing going in bodybuilding/sports supplements.

About the Author - William D. Brink

Will Brink is a columnist, contributing consultant, and writer for various health/fitness, medical, and bodybuilding publications. His articles relating to nutrition, supplements, weight loss, exercise and medicine can be found in such publications as Lets Live, Muscle Media 2000, MuscleMag International, The Life Extension Magazine, Muscle n Fitness, Inside Karate, Exercise For Men Only, Body International, Power, Oxygen, Penthouse, Women’s World and The Townsend Letter For Doctors.

He is the author of Priming The Anabolic Environment , Body Building Revealed & Fat Loss Revealed. He is the Consulting Sports Nutrition Editor and a monthly columnist for Physical magazine, Musclemag and an Editor at Large for Power magazine. Will graduated from Harvard University with a concentration in the natural sciences, and is a consultant to major supplement, dairy, and pharmaceutical companies.

He has been co author of several studies relating to sports nutrition and health found in peer reviewed academic journals, as well as having commentary published in JAMA. He runs the highly popular web site BrinkZone.com which is strategically positioned to fulfill the needs and interests of people with diverse backgrounds and knowledge. The BrinkZone site has a following with many sports nutrition enthusiasts, athletes, fitness professionals, scientists, medical doctors, nutritionists, and interested lay people. William has been invited to lecture on the benefits of weight training and nutrition at conventions and symposiums around the U.S. and Canada, and has appeared on numerous radio and television programs.

William has worked with athletes ranging from professional bodybuilders, golfers, fitness contestants, to police and military personnel.

See Will's ebooks online here:

Brink's BodyBuilding Revealed

"Bodybuilding Revealed is a complete blue print to muscle building success. Everything you need to know about diet & muscle building nutrition, over 50 bodybuilding supplements reviewed, weight training routines, high intensity cardio, the mental edge, pre made muscle building diets and an online private members forum, diet planner, meal planner and much more. It's all in Will Brink's ultimate guide to gaining muscle mass."

Fat Loss Revealed

"Fat Loss Revealed is the ultimate fat loss manual. A complete online and offline system used by anybody looking to attain a fantastic lean physique. A complete fat loss diet plan, with pre made diets, over 40+ fat loss supplement reviews, resistance workouts, and cardio , along with motivation and goal setting and a huge online private members area and forum form Will Brink's Ultimate Fat loss Program.

Christian Bodybuilding?